The Effect of Mast Cells Stimulated by Toll-Like Receptors on Keratinocytes

نویسندگان

چکیده

Abstract The mast cells, as located in the skin’s dermal layer, are important innate immune cells that mediate inflammation a defense response against outer pathogens. Mast activated by receptors such Toll-like receptrs (TLRs) and interact with variety of including keratinocytes. This study confirmed effect TLRs-stimulated on migration keratinocytes residing epidermis. HaCaT human keratinocyte cell line, was treated concentrated conditioned medium (CM) HMC-1, line. After that, migratory capacity via scratch transwell assays. In addition, we tried to confirm whether TLRs activations affect these effects migration. Thus same experiments were carried out using CM HMC-1 obtained under various stimulation agonist. As result, HMG-1 promoted ability assay assay. Those further increased when exposed stimulation. work supported grant National Research Foundation Korea (NRF) funded Government (MSIT) (NRF-2021R1A2C1012551).

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ژورنال

عنوان ژورنال: Journal of Immunology

سال: 2023

ISSN: ['1550-6606', '0022-1767']

DOI: https://doi.org/10.4049/jimmunol.210.supp.70.16